Exploring the mechanism of Zengye Decoction in treating Sjogren's syndrome based on network pharmacology / 国际中医中药杂志

ABSTRACT

Objective:To investigate the core components and mechanism of Zengye Decoction in the treatment of Sjogren's syndrome (SS) by using network pharmacology. Methods:By using BATMAN-TCM database to obtain the main components and targets of Zengye Decoction. The target gene of SS was obtained by DISGeNET database and CTD database. The common part of Zengye Decoction and SS target was obtained by Omicshare platform. Analyzing the common protein interaction by string database and uploading common targets to the DAVID website for GO and KEGG enrichment analysis, then applying Cytoscape 3.6.1 for results analysis and network visualization. Results:9 active components and 25 core targets were screened. DAVID analysis obtained 29 biological processes and 25 related pathways. L-Asparagine, Ophiopogonanone E, Methyl Ophiopogonanone B are the main components acting on PI3K/AKT pathway, mTOR pathway, and TLR pathway, etc.Conclusions:Zengye Decoction plays an integrative role of treating Sjogren's syndrome with the multi-component, multi-target, multi-channel charaters. This paper provides a theoretical basis for further exploration of the mechanism research of Zengye Decoction in the treatment of SS.