Clinical significance of changes of inflammatory cytokines level in trauma patients / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12): 1333-1336, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-863860
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To explore the clinical significance and underlying mechanism of changes in serum IL - 18 and IL - 1 beta after trauma.Methods:
Enzyme-linked immunosorbent assay was used to detect the levels of IL-18 and IL-1β in trauma patients and healthy controls. The differences in serum IL-18 and IL-1β levels were compared between the two groups, and the levels of IL-18 and IL-1β in the traumatic subgroups were further compared.Results:
The serum levels of IL-1β and IL-18 of trauma patients were 80±2.0 pg/mL and 27±3.0 pg/mL, respectively, which were significantly higher than those in healthy controls ( P < 0.01). Serum levels of IL-1β and IL-18 showed an upward trend on the 3rd day after trauma. There were also statistically significant differences within the trauma subgroups ( P < 0.01).Conclusions:
The serum levels of IL-18 and IL-1β of post-traumatic patients are increased, indicating that NLRP3 inflammasomes are activated in peripheral blood cells in the early stage of trauma, which aggravates the inflammatory response. The AIS-ISS score is positively correlated with the expression levels of IL-18 and IL-1β in serum, indicating that the more severe the injury, the more severe the inflammatory response.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Emergency Medicine
Ano de publicação:
2020
Tipo de documento:
Artigo