Correlation between the level of serum adiponectin and uric acid and retinopathy in type 2 diabetes mellitus

Xiuxiu WANG; Hui YIN; Yaqiong WANG

ABSTRACT

Objective:

To observe the changes of serum adiponectin and uric acid levels in patients with type 2 diabetes mellitus (T2DM) , and to investigate its correlation with diabetic retinopathy (DR) .

Methods:

Data of 120 hospitalized T2DM patients in our hospital from Jun. 2017 to Jun. 2019 were retrospectively analyzed. According to the fundus findings, they were divided into no DR group (40 cases) , hyperplastic DR group (45 cases) and non-proliferative DR group (35 cases) . 30 healthy cases in the same period were selected as the control group. The level of aboratory biochemical indexes, serum adiponectin and uric acid were compared between the 4 groups. Risk factors affecting DR were analyzed by Logistic multivariate regression.

Results:

There was no significant difference in TC among the four groups ( P>0.05) . There were significant differences in TG, LDL-C, HDL-C, HbA1c, and FPG among the four groups ( F=1.638, 0.582, 2.715, 5.382, 5.174, P=0.007, 0.016, 0.028, 0.003, 0.001) . TG, HbA1c, and FPG of DR group, non-proliferative DR group and proliferative DR group were significantly higher than those of the control group (no DR group vs the control group t=2.246, 12.440, 14.539, P=0.028, 0.000, 0.000; Non-hyperplastic DR group vs the control group t=3.127, 14.775, 14.767, P=0.000; Hyperplastic DR group vs the control group t=3.349,16.197,12.755, P=0.001,0.000,0.000) , and the level of these indexes were rising with the aggravation of the disease. HDL-C of DR group, non-proliferative DR group and proliferative DR group were significantly lower than that of the control group (non-hyperplastic DR group vs the control group t=2.113, P=0.040; DR group vs the control group t=2.778, P=0.007) , and decreased with the aggravation of the disease. There were significant differences in the level of serum adiponectin and uric acid among the four groups ( F=4.728, 26.491, P=0.004, 0.001) . The level of serum adiponectin was significantly lower in no DR group, non-proliferative DR group and proliferative DR group than that in the control group (no DR group vs the control group t=2.227, P=0.031; Non-hyperplastic DR group vs the control group t=5.198, P=0.000; Hyperplastic DR group vs the control group t=6.827, P=0.000) , and decreased with the aggravation of the disease. The level of serum uric acid in the DR group, non-proliferative DR group and proliferative DR group were significantly higher than those in the control group (No DR group vs the control group t=5.681, P=0.000; Non-hyperplastic DR group vs the control group t=13.688, P=0.000; Hyperplastic DR group vs the control group t=23.620, P=0.000) , and increased with the aggravation of the disease. Multivariate Logistic regression analysis showed that the course of diabetes, HbA1c, adiponectin and uric acid were independent risk factors affecting DR.

Conclusions:

The level of serum adiponectin decreases in DR patients, and the level of serum uric acid increases in DR patients, which relates to DR progress. Adiponectin and uric acid are risk factors affecting DR.