Evolution of antibiotic resistance of Streptococcus pneumoniae in children / 中华实用儿科临床杂志

ABSTRACT

Streptococcus pneumoniae is the dominant pathogen of respiratory tract infections in children.Due to the long-term overuse of antibiotics, the growing resistance of Streptococcus pneumoniae against many kinds of antimicrobial agents, including the β-lactamides, the macrolides, the fluoroquinolones and so on, increasing infections caused by drug-resistant pneumococcal isolates, as well as the wide prevalence of such infections have posed great challenges to the selection of antibiotics in clinical practice.In this article, changes of resistance patterns of Streptococcus pneumoniae isolates against commonly used antimicrobial agents in Chinese children in the past 30 years were reviewed.The rapid development of antibiotic resistance of Streptococcus pneumoniae necessitates the prevention and control of Streptococcus pneumoniae infections as well as the reduction of unreasonable use of antibiotics.