Progress in application of new biological biomarkers in the diagnosis of pediatric tuberculosis / 中华实用儿科临床杂志

ABSTRACT

Tuberculosis is still a serious disease threatening children′s health.The detection and early diagnosis of tuberculosis in children still face many problems, such as the low detection rate and high misdiagnosis rate from traditional methods, the difficulty of collection and low bacterial load of sputum specimens from children, and difficult diagnosis of extrapulmonary tuberculosis.Therefore, there is an urgent need to find new diagnostic markers for rapid, sensitive and efficient diagnosis of tuberculosis, and biomarkers point out the direction for us.In this review, progress in the application of new biological biomarkers of pediatric tuberculosis was summarized from the transcriptomic, proteomic, metabolomic and microRNA aspects.