Research progress on the relationship between Vitamin D deficiency and neonatal lung development / 中华实用儿科临床杂志

ABSTRACT

Vitamin D deficiency is common among pregnant women and newborns, and Vitamin D plays an important role in the neonatal lung development.Animal experiments proved that Vitamin D has a significant effect on type Ⅱ alveolar cell proliferation, fibroblast proliferation, surfactant synthesis and alveolarization.Clinical studies revealed that there is a higher proportion of assisted ventilation, respiratory distress syndrome(RDS)and bronchopulmonary dysplasia(BPD), and longer aerobic duration in neonates with Vitamin D deficiency.Therefore, this article systematically reviewed the effects of Vitamin D on lung development, surfactant synthesis, RDS, and BPD.