Effects of low dose mifepristone combined with dydrogesterone tablets on uterine volume and dysmenorrhea in patients with adenomyosis

Zhili TANG

ABSTRACT

Objective:

To observe the effect of low-dose mifepristone combined with dydrogesterone tablets on uterine volume and dysmenorrhea in patients with adenomyosis.

Methods:

From January 2019 to January 2020, 82 patients with adenomyosis who were diagnosed and treated in the department of obstetrics and gynecology of the People's Hospital of Changxing County were selected and divided into two groups according to the random number table method, with 41 cases in each group.The observation group was treated with low-dose mifepristone combined with dydrogesterone tablets, and the control group was treated with levonorgestrel intrauterine system.The clinical efficacy of the two groups after treatment was observed, and the uterine volume, dyenorrhea, estradiol(E 2), luteinosin(LH), serum follicle-stimulating hormone(FSH) and carbohydrate antigen 125(CA125) before and after treatment were counted.

Results:

After treatment, the total effective rate of the observation group was higher than that of the control group(80.49% vs.97.56%, χ 2=6.116, P<0.05). Before treatment, the uterine volume between the two groups had no statistically significant difference ( t=0.165, P>0.05). After treatment, the uterine volume of both two groups was reduced compared with before treatment ( t=17.541, 36.940, all P<0.001). And the uterine volume of the observation group was significantly smaller than that of the control group ( t=-39.506, P<0.001). Before treatment, the degree of dysmenorrhea between the two groups had no statistically significant difference ( t=0.603, P>0.05). After treatment, the degree of dysmenorrhea in both two groups was reduced compared with before treatment ( t=26.100, 46.610, all P<0.001). The score of dysmenorrhea in the observation group was significantly lower than that in the control group( t=20.327, P<0.001). Before treatment, the levels of E 2, LH, FSH and CA125 between the two groups had no statistically significant differences( t=0.124, 0.502, 0.222, 0.084, all P>0.05). After treatment, the levels of E 2, LH, FSH and CA125 in the two groups were improved.And the E 2 and CA125 levels of the observation group were better than those of the control group ( t=-3.392, 6.171, 2.619, 18.728, -9.889, 4.582, 2.572, 23.629, all P<0.05), while the LH and FSH levels of the two groups had no statistically significant differences ( t=6.064, 1.108, 1.166, -7.392, all P>0.05).

Conclusion:

The treatment of adenomyosis with mifepristone combined with dydrogesterone tablets is effective, it can effectively reduce the uterine volume, reduce dysmenorrhea, improve the sex hormone levels of patients, which is worthy of clinical promotion.