Autologous fat injection for the treatment of pathological scars / 中华皮肤科杂志

ABSTRACT

Pathological scars mostly result from abnormal remodeling after skin trauma, and they are characterized by dysregulated fibroblast proliferation and extracellular matrix deposition. In recent years, several studies have confirmed that autologous fat injections contain a variety of substances that may be involved in the treatment of scars, such as stromal vascular fraction, adipose-derived mesenchymal stem cells and so on. These substances can inhibit the excessive proliferation of fibroblasts and deposition of collagen through related pathways, so as to slow the progression and improve the prognosis of pathological scars. Clinical studies have demonstrated that fat injections can effectively ameliorate the thickness, color, softness and local symptoms of pathological scars. Further understanding of the anti-fibrosis mechanism of adipose tissues will facilitate the development of therapies for pathological scars.