NLRP6 as a Negative Regulator of Innate Immunity
Journal of Bacteriology and Virology
; : 64-66, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-87590
Biblioteca responsável:
WPRO
ABSTRACT
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Linfócitos B
/
Interferon Tipo I
/
Transformação Celular Neoplásica
/
Colite
/
Proteínas do Citoesqueleto
/
Inflamassomos
/
Imunidade Inata
/
Listeria monocytogenes
Limite:
Animais
Idioma:
Inglês
Revista:
Journal of Bacteriology and Virology
Ano de publicação:
2013
Tipo de documento:
Artigo