Resveratrol inhibits hypoxia-induced oxidative stress and proliferation in pulmonary artery smooth muscle cells through the HIF-1α/NOX4/ROS signaling pathway / 生理学报
Acta Physiologica Sinica
; (6): 551-558, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-878200
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of the present study was to determine the effects of resveratrol on hypoxia-induced oxidative stress and proliferation in pulmonary artery smooth muscle cells (PASMCs) and the underlying mechanism. Primary rat PASMCs were isolated and cultured in vitro and pretreated with different concentrations of resveratrol (10, 20, and 40 µmol/L) or the NADPH oxidase (NOX) inhibitor VAS2870 (10 µmol/L) for 0.5 h. The cells were then cultured under normoxia (21% O
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artéria Pulmonar
/
Transdução de Sinais
/
Células Cultivadas
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Miócitos de Músculo Liso
/
Proliferação de Células
/
NADPH Oxidase 4
/
Resveratrol
/
Hipóxia
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2020
Tipo de documento:
Artigo
