Mechanism, prevention, and treatment for medication-related osteonecrosis of the jaws / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 245-254, 2021.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-878439
Biblioteca responsável:
WPRO
ABSTRACT
The morbidity rate of medication-related osteonecrosis of the jaws (MRONJ) increased rapidly in recent years. Thusfar, the mechanism of MRONJ has no consensus. The possible mechanisms may include bone remodeling inhibition theory, angiogenesis inhibition theory, oral microorganism infection theory, immunosuppression theory, cytotoxicity-targeted oral epithelial cells, microcrack formation of maxillary or mandibular bone, and single nucleotide polymorphism. However, the efficacy of prevention and treatment based on a single mechanism is not ideal. Routine oral examination before MRONJ-related drug treatment, treatment of related dental diseases, and regular oral follow-up during drug treatment are of great significance for the prevention of MRONJ. During the treatment of MRONJ, the stage of MRONJ must be determined accurately, treatment must be standardized in accordance with the guidelines, and personalized adjustments must be made considering the specific conditions of patients. This review aimed to combine the latest research and guidelines for MRONJ and the experiences on the treatment of MRONJ in the Maxillofacial Surgery Department of West China Hospital of Stomatology, Sichuan University, and discuss the strategies to improve the clinical process.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
China
/
Remodelação Óssea
/
Conservadores da Densidade Óssea
/
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos
/
Arcada Osseodentária
Tipo de estudo:
Guia de prática clínica
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
West China Journal of Stomatology
Ano de publicação:
2021
Tipo de documento:
Artigo