Research progress on long non-coding RNA (lncRNA) in osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 1085-1088, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-879358
Biblioteca responsável:
WPRO
ABSTRACT
Osteoarthritis(OA) is a common clinical disease. The incidence of OA increases significantly with age, and the quality of life of patients is seriously affected. In the pathogenesis of OA, cartilage degeneration is the main cause. There are many long non-coding RNA (lncRNA) specifically expressed in osteoarthritis, which is closely related to the occurrence and development of osteoarthritis. Based on the latest research from 2014 to 2019, this paper summarizes the differential expression of lncRNA in osteoarthritis, the mechanism of lncRNA regulating chondrocyte function, and the mechanism of lncRNA regulating cartilage matrix metabolism. The fact that the expression of lncRNA is altered at different stages of OA development indicates that lncRNA can be developed forlife. The biomarkers and therapeutic targets can provide reference for the prevention, treatment and research of osteoarthritis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoartrite
/
Qualidade de Vida
/
Pesquisa
/
Condrócitos
/
RNA Longo não Codificante
Aspecto:
Preferência do paciente
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2020
Tipo de documento:
Artigo