Clinical characteristics and prognostic analysis of pediatric pro-B cell acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1286-1294, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-879791
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore the clinical-biological characteristics and prognosis of pediatric pro-B cell acute lymphoblastic leukemia (pro-B-ALL).@*METHODS@#A total of 64 patients aged less than 18 years old with pro-BALL were enrolled. Clinical characteristics, therapeutic effect and prognostic factors were retrospectively analyzed.@*RESULTS@#Pro-B-ALL occurred in 6.23% (64/1 028) of pediatric ALL. Among the 64 patients, 35 were male and 29 were female. The median age was 7.0 years (range 0.4-16.0 years) at diagnosis, of which 39% and 6% were ≥ 10 years old and < 1 year old respectively. The median WBC count was 25.5×10@*CONCLUSIONS@#Pediatric pro-B ALL is a heterogeneous disease with clinical and biological diversity. Biological characteristics, such as immunological markers, genetic alterations, and MRD at 3 months after chemotherapy may be important factors for the long-term prognosis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
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Leucemia-Linfoma Linfoblástico de Células Precursoras B
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Antígenos CD
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Estudos Retrospectivos
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Histona-Lisina N-Metiltransferase
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Neoplasia Residual
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Intervalo Livre de Doença
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Proteína de Leucina Linfoide-Mieloide
Tipo de estudo:
Estudo observacional
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Estudo prognóstico
Limite:
Adolescente
/
Criança
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Criança, pré-escolar
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Feminino
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Humanos
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Lactente
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2020
Tipo de documento:
Artigo