Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 1101-1107, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-880229
Biblioteca responsável:
WPRO
ABSTRACT
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has some characteristics worth studying, such as correlation with patients' poor prognosis. Multiple chromosomal events are involved in the formation of ecDNA, and its amplification can directly increase the number of DNA copies of extra-chromosomal oncogenes and accelerate the generation and development of tumors. Moreover, the segregation pattern of unequal transmission of parental ecDNA cells to offspring not only increases tumor heterogeneity, but also enhances tumor adaptation to environment and response to therapy. This article reviews the current status and potential significance of ecDNA in tumor cells.
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Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Lung Cancer
Ano de publicação:
2020
Tipo de documento:
Artigo