Progress in study on the association between HLA genetic variation and adverse drug reactions / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 404-413, 2021.
Article
em En
| WPRIM
| ID: wpr-880674
Biblioteca responsável:
WPRO
ABSTRACT
The human leukocyte antigen (HLA) molecules encoded within the human major histocompatibility complex are a group of highly conserved cell surface proteins, which are related to antigen recognition. HLA genes display a high degree of genetic polymorphism, which is the basis of individual differences in immunity. Specific HLA genotypes have been highly associated with typical adverse drug reactions. HLA-A*31:01 and HLA-B*15:02 are associated with carbamazepine-induced severe cutaneous adverse reactions, HLA-B*57:01 is related to abacavir-induced drug-induced hypersensitivity syndrome and flucloxacillin/pazopanib-induced drug-induced liver injury, while HLA-B*35:01 is a potential biomarker for predicting polygonum multiflorum-induced liver injury. It is not clear how small drug molecules to interact with HLA molecules and T cell receptors (TCR). There are four mechanistic hypotheses, including the hapten/prohapten theory, the pharmacological interaction concept, the altered peptide repertoire model, and the altered TCR repertoire model.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Genótipo
/
Antígenos HLA
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2021
Tipo de documento:
Article