Development and validation of an individualized nomogram for early prediction of the duration of SARS-CoV-2 shedding in COVID-19 patients with non-severe disease / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 318-329, 2021.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-880732
Biblioteca responsável:
WPRO
ABSTRACT
With the number of cases of coronavirus disease-2019 (COVID-19) increasing rapidly, the World Health Organization (WHO) has recommended that patients with mild or moderate symptoms could be released from quarantine without nucleic acid retesting, and self-isolate in the community. This may pose a potential virus transmission risk. We aimed to develop a nomogram to predict the duration of viral shedding for individual COVID-19 patients. This retrospective multicentric study enrolled 135 patients as a training cohort and 102 patients as a validation cohort. Significant factors associated with the duration of viral shedding were identified by multivariate Cox modeling in the training cohort and combined to develop a nomogram to predict the probability of viral shedding at 9, 13, 17, and 21 d after admission. The nomogram was validated in the validation cohort and evaluated by concordance index (C-index), area under the curve (AUC), and calibration curve. A higher absolute lymphocyte count (
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Meta 3.8 Atingir a cobertura universal de saúde
/
Pneumonía
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Modelos de Riscos Proporcionais
/
Estudos Retrospectivos
/
Eliminação de Partículas Virais
/
Contagem de Linfócitos
/
Área Sob a Curva
/
Carga Viral
/
Nomogramas
/
COVID-19
/
Anticorpos Antivirais
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2021
Tipo de documento:
Artigo