Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 952-956, 2020.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-881041
Biblioteca responsável:
WPRO
ABSTRACT
Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins (1-9) were identified from a recombinant mutant strain S35-LAL by overexpressed the large-ATP-binding regulator of the LuxR family (LAL) gene aas1 in Streptomyces sp. S35. All the compounds showed no anti-microbial, anti-T3SS and cytotoxic activities.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Streptomyces
/
Produtos Biológicos
/
Família Multigênica
/
Organismos Geneticamente Modificados
/
Lactamas Macrocíclicas
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2020
Tipo de documento:
Artigo