Acute promyelocytic leukemia combined with hereditary fibrinogen deficiency: report of one case and review of literature / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 286-289, 2021.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-882278
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To improve the clinical recognition of hereditary fibrinogen deficiency.Methods:
The diagnosis and treatment process of a patient with acute promyelocytic leukemia (APL) complicated with hereditary fibrinogen deficiency who was admitted to the second Affiliated Hospital of Anhui Medical University in December 2018 was retrospectively analyzed, and the relevant literature was reviewed.Results:
The patient was initially diagnosed as APL, and the complete remission was obtained after dual-induction therapy of all-trans retinoid acid and arsenous acid. During the first consolidation treatment, repeated reviews of fibrinogen fluctuated between 1.0-1.5g/L, and further improving the fibrinogen gene sequencing to diagnose APL combined with hereditary fibrinogen deficiency.Conclusion:
For APL patients in remission who have decreased fibrinogen for many times and patients with hereditary fibrinogen deficiency who have significantly decreased fibrinogen in a short period, bone marrow biopsy and genetic testing should be further conducted to determine the pathogenesis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2021
Tipo de documento:
Artigo