Transcription factor TBX20 and pathogenesis of congenital heart disease / 国际儿科学杂志
International Journal of Pediatrics
; (6): 302-305, 2021.
Article
em Zh
| WPRIM
| ID: wpr-882346
Biblioteca responsável:
WPRO
ABSTRACT
TBX20 gene, a member of the T-box gene family, plays an important role during heart development and is required for maintaining adult heart function.TBX20 can act as both transcriptional activator and transcriptional suppressor during the development of the heart, and shows complex spatiotemporal regulation.TBX20 is an important candidate transcription factor for the pathogenesis of congenital heart disease(CHD), and its mutation or expression change can lead to the occurrence of CHD.In this paper, the latest research progress of TBX20 gene in the field of heart development is reviewed from the relationship between TBX20 and CHD, the signaling pathway involved in heart development and its interactions with other cardiac transcription factors.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Etiology_studies
Idioma:
Zh
Revista:
International Journal of Pediatrics
Ano de publicação:
2021
Tipo de documento:
Article