Progress of coxsackievirus A10 / 国际儿科学杂志

ABSTRACT

Hand, foot and mouth disease(HFMD)is a common class C infectious disease for children under 5 years of age in our country, which pathogens are multiple enteroviruses.Recent studies have found that coxsackievirus A10(CVA10)has become one of the main pathogens of HFMD gradually, and its infection is on the rise.Moreover, enterovirus 71(EV71), coxsackievirus A16(CVA16), coxsackievirus A6(CVA6), and CVA10 co-circulate has appeared.The CVA10 cell receptor is recombinant kringle containing transmembrane protein 1(KRM1), and the specific neutralizing antibody is named 2G8.The vaccines in related animal models are inactivated vaccines and virus-like particle vaccines.This paper reviews on aspects of cell receptors, neutralizing antibodies, vaccines researches and animal models about CVA10, providing some ideas for the prevention and control of HFMD.