Interstitial Lung Disease in Connective Tissue Disease
Journal of Rheumatic Diseases
; : 282-288, 2014.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-8950
Biblioteca responsável:
WPRO
ABSTRACT
Interstitial lung disease (ILD) is one of the most serious pulmonary complications of connective tissue diseases (CTDs), resulting in significant morbidity and mortality. ILD is frequently seen in CTDs, particularly systemic sclerosis, polymyositis/dermatomyositis, and rheumatoid arthritis; however, determining that ILD is associated with an established CTD requires the exclusion of alternative causes. Non-specific interstitial pneumonia is the most commonly observed histopathological pattern in CTD-associated ILD (CTD-ILD) except for rheumatoid arthritis, characterized by a higher frequency of usual interstitial pneumonia. Although CTD-ILD usually shows a stable or slowly progressive course, a subgroup exhibits a more severe and progressive course and requires pharmacologic intervention. Treatment strategies typically involve empirical use of immunosuppressive therapies, although a large, randomized study has examined the impact of immunosuppressive therapy for systemic sclerosis associated ILD and should also address comorbid conditions considering implementation of adjunctive therapeutic strategies. A subgroup of patients with idiopathic interstitial pneumonia who meet some, but not all, diagnostic criteria for CTDs were identified and well organized prospective studies are needed in to better determine whether evidence of autoimmunity in those plays a part in the evolution to well-defined CTDs or carries prognostic significance.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças Imunológicas
/
Doenças Musculoesqueléticas e Reumáticas
/
Outras Neoplasias Malignas
/
Outras Doenças Respiratórias
/
Doenças da Pele
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Escleroderma Sistêmico
/
Autoimunidade
/
Mortalidade
/
Doenças Pulmonares Intersticiais
/
Doenças do Tecido Conjuntivo
/
Pneumonias Intersticiais Idiopáticas
/
Fibrose Pulmonar Idiopática
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2014
Tipo de documento:
Artigo