Short-, Intermediate-, and Long-Term Changes in Basophil Reactivity Induced by Venom Immunotherapy
Allergy, Asthma & Immunology Research
; : 412-420, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-90244
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant decrease in basophil activation during 5 years of VIT and clinical protection assessed by sting challenge. The following prospective study was performed to examine changes in basophil reactivity over a complete VIT period of 5 years.METHODS:
BAT in a dose-response curve was studied prospectively in 10 hymenoptera venom-allergic patients over 5 years of VIT. BAT was performed at the time of diagnosis, 1 month after finishing the VIT build-up phase, and 3, 6, 12, 24, and 60 months after beginning treatment. The repeated measures ANOVA was applied to evaluate basophil activation changes throughout VIT. A cross-sectional study was also performed in 6 patients who received treatment for more than 3 years, and in another 12 patients who followed immunotherapy for at least 5 years.RESULTS:
An early activation decrease was observed during the first 3 months of treatment, compared to pre-treatment values. This activation decrease was not maintained 6 to 18 months after treatment, but was observed again after 2 years of treatment, and maintained until the completion of the 5-year immunotherapy period. In cross-sectional analysis, the 6 patients who received treatment for 3 years, and 9 of the 12 patients who received treatment for 5 years, had negative BAT results. Three patients in this last group had positive BAT results and 2 patients had systemic reactions after field stings.CONCLUSIONS:
BAT appears to be an optimal non-invasive test for close monitoring of VIT.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peçonhas
/
Basófilos
/
Mordeduras e Picadas
/
Estudos Transversais
/
Estudos Prospectivos
/
Sensibilidade e Especificidade
/
Diagnóstico
/
Himenópteros
/
Imunoterapia
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2016
Tipo de documento:
Artigo