APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 823-833, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-90557
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. MATERIALS ANDMETHODS:
Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1.RESULTS:
Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548+/-0.333 ng/100 muL [n=51] for bladder cancer vs. 1.547+/-0.319 ng/100 muL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence.CONCLUSION:
Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Radioterapia
/
Recidiva
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Ensaio de Imunoadsorção Enzimática
/
Biomarcadores
/
Curva ROC
/
Sensibilidade e Especificidade
/
Tratamento Farmacológico
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Cancer Research and Treatment
Ano de publicação:
2015
Tipo de documento:
Artigo