Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? / 대한배뇨장애요실금학회지
International Neurourology Journal
; : 164-170, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-90690
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse.METHODS:
Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision.RESULTS:
Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P=0.018) and menopause (P=0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P=0.006).CONCLUSIONS:
The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin-1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prolapso
/
Incontinência Urinária
/
Peso ao Nascer
/
Menopausa
/
Expressão Gênica
/
Prolapso Uterino
/
Retocele
/
Parto
/
Matriz Extracelular
/
Cistocele
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
International Neurourology Journal
Ano de publicação:
2015
Tipo de documento:
Artigo