Progress of allogeneic hematopoietic stem cell transplantation for hyper IgM syndrome / 国际儿科学杂志
International Journal of Pediatrics
; (6): 386-390, 2021.
Article
em Zh
| WPRIM
| ID: wpr-907244
Biblioteca responsável:
WPRO
ABSTRACT
Hyper immunoglobulin M syndrome(HIGM)is a group of rare primary immunodeficiency disease(PID)caused by single gene mutation.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the only treatment to cure the disease, and patients should receive allo-HSCT if possible.Younger patients who can keep in good pre-transplant state, obtain matching sibling donor and tolerate to myeloablative conditioning may get better outcome after early transplantation, and the overall survival rate can reach 80%.The progress in the timing of transplantation, donor and graft, conditioning regimen, prevention and treatment of complications of allo-HSCT for HIGM is reviewed in this paper.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
International Journal of Pediatrics
Ano de publicação:
2021
Tipo de documento:
Article