Research progress in mechanism of mesenchymal stem cells-derived exosomes treating spinal cord injury / 中华创伤杂志
Chinese Journal of Trauma
; (12): 171-175, 2021.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-909850
Biblioteca responsável:
WPRO
ABSTRACT
Secondary injury and the glial scar after spinal cord injury can adversely affect nerve regeneration in the microenvironment, leading to treatment difficulties. Mesenchymal stem cells (MSCs) have multi-differentiation, self-renewal ability, participation in immune regulation and other functions and can be used to treat spinal cord injury, but they are not easy to pass the blood spine barrier and have high tumorigenicity and other disadvantages. MSCs-derived exosomes are nanometer exosomes secreted by MSCs, which contain many active substances. These exosomes have a strong neurorepair effect in spinal cord injury research, and have advantages of easy penetration, stability and low tumorigenicity, etc. These exosomes make up for the disadvantages of MSCs treatment, and are expected to replace MSCs in treatment of spinal cord injury. The authors review the biological characteristics of MSCs-derived exosomes and its mechanism in the treatment of spinal cord injury, so as to provide references for the treatment of spinal cord injury.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Trauma
Ano de publicação:
2021
Tipo de documento:
Artigo