Effect and mechanism of bone microenvironment on healing of osteoporotic fractures / 中华创伤杂志

ABSTRACT

The osteoporotic fracture is characterized by difficult treatment and poor prognosis. The studies of bone biology show that bone microenvironment changes during osteoporotic fractures，such as changes in immune factors，abnormal chemotaxis and differentiation of mesenchymal stem cells（MSCs），decreased estrogen secretion and receptor down-regulation and decreased mechanical sensitivity，which affect the fracture healing process. Current studies have shown that by improving the phenotypic polarization of macrophages，enhancing the chemotactic osteogenic activity of MSCs，supplementing estrogen and improving the biomechanical properties of bone can remodel the balance of bone microenvironment，thereby effectively improve the bone quality. The authors explore the effect and mechanism of bone microenvironment on healing of osteoporotic fractures from the perspectives of changes in bone microenvironment and imbalance of bone microenvironment that affect fracture healing and methods of bone microenvironment reconstruction，so as to provide new ideas for clinical treatment of osteoporotic fractures.