Association between Cerebral Small Vessel and Alzheimer’s Disease
Journal of the Korean Radiological Society
; : 486-507, 2022.
Article
em En
| WPRIM
| ID: wpr-926441
Biblioteca responsável:
WPRO
ABSTRACT
Cerebral small vessel disease (CSVD) includes vascular lesions detected on brain MRI, such as white matter hyperintensities, lacunar infarctions, microbleeds, or enlarged perivascular spaces. There is accumulating evidence that vascular changes may play an important role in development of Alzheimer’s disease (AD), and CSVD lesions detected on brain MRI were reported to be associated with β-amyloid and tau proteins accumulation. As the vascular contribution has therapeutic potential, it is important to understand the association of CSVD with AD and AD biomarkers. This review begins with a brief introduction of AD and AD biomarkers, explains the association between AD and vascular changes, and then details the pathogenesis and MR imaging findings of CSVD. Afterwards, we discuss the association of CSVD with AD and AD biomarkers.
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Base de dados:
WPRIM
Idioma:
En
Revista:
Journal of the Korean Radiological Society
Ano de publicação:
2022
Tipo de documento:
Article