Parental predisposition to atopy and bronchial hyperresponsiveness / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
; : 695-702, 2002.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-93466
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Atopy and bronchial hyperresponsiveness (BHR) which are characteristics of asthma, are strongly correlated but independently inherited traits. The relative contribution of maternal and paternal condition to the risk of offspring's condition is not certain.OBJECTIVE:
The aim of this study was to evaluate maternal or paternal contribution to childhood atopy and BHR in a population-based sample of 140 Korean nuclear families. SUBJECTS ANDMETHODS:
A total of 486 subjects (133 mothers, 132 fathers and 221 offsprings) participated in this study. All subjects provided questionnaire data and 483 subjects underwent allergy skin prick test with 13 inhalant allergens. Total serum IgE levels were determined in 444 subjects and methacholine bronchial provocation test were performed in 483 subjects.RESULTS:
Serum total IgE level in the offspring was correlated with both maternal and paternal total IgE (mother R=0.273, p<0.01; father R=0.200, p<0.01). Bronchial hyperres ponsiveness was associated with parental atopy index (mother R=0.175, p<0.01; father R=0.205, p<0.01) and maternal BHR(R=0.201, p<0.01). The development of wheezing in the offspring was significantly associated with maternal BHR, but not paternal.CONCLUSION:
These results suggest that maternal BHR does confer more risk than paternal BHR to risk of offspring's BHR.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pais
/
Asma
/
Pele
/
Testes de Provocação Brônquica
/
Imunoglobulina E
/
Alérgenos
/
Núcleo Familiar
/
Sons Respiratórios
/
Inquéritos e Questionários
/
Cloreto de Metacolina
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Ano de publicação:
2002
Tipo de documento:
Artigo