Progress of microbiota-gut-brain axis in the pathogenesis of white matter injury in preterm infants / 国际儿科学杂志

ABSTRACT

White matter injury in preterm infants is a unique form of brain injury.It is one of the most common cause of chronic neurological diseases such as cerebral palsy and various neurobehavioral disorders.Perinatal infection, inflammation and hypoxic ischemia are related to the pathophysiology of white matter injury in preterm infants.Signals released by the gut microbiota, such as microbial metabolites, can modulate inflammatory and immune responses characterized by microglial activation, and ultimately it affects the differentiation of premyelin oligodendrocytes and causes white matter injury in preterm infants.Recently more attention has been paid to the role of gut microbiota in the pathogenesis of white matter injury in preterm infants.This article reviews the progress of "microbiota-gut-brain axis" involved in the pathogenesis of white matter injury in preterm infants, so as to provide reference for further prevention and treatment of white matter injury.