Neonatal Hepatic Hemangioendothelioma: A Single Institute Experience / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 46-52, 2016.
Article
em Ko
| WPRIM
| ID: wpr-97104
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Hepatic hemagioendothelioma in neonatal period was rarely seen, so standard treatment does not established yet. METHODS: A retrospective analysis of patients with neonatal hepatic hemangioendothelioma at Ajou University Hospital between 2001 and 2016 was performed. RESULTS: Six patients with hepatic hemangioendothelioma in neonatal period were founded. Mean age at diagnosis was 6.1 days (range, 1-26 days). Three patients have no symptoms; diagnostic approach was prenatal ultrasonography in 2 patients, and incidental abnormal ultrasonographic findings in 1 patient, but the other 3 patients have hepatomegaly and/or congestive heart failure. Three patients were observed without treatment and the other 3 patients received medical and/or surgical treatment. Three patients of those who did not receive treatment became spontaneous regression. Of the other 3 patients, 1 patient achieved complete tumor disappearance after surgical resection, another 1 patient achieved to decrease tumor size with interferon-alpha treatment for 6 months and then had complete resolution of tumor after partial liver lobectomy, and other 1 patient who received hepatic artery embolization decreased in the size and number of lesions and then regressed gradually. CONCLUSION: Asymptomatic patients with neonatal hepatic hemangioendothelioma could have spontaneous remission, but patients with symptoms such as hepatomegaly with congestive heart failure or thrombocytopenia needed to be applied with medical and/or surgical treatment.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Remissão Espontânea
/
Trombocitopenia
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Estudos Retrospectivos
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Ultrassonografia Pré-Natal
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Interferon-alfa
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Diagnóstico
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Insuficiência Cardíaca
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Hemangioendotelioma
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Artéria Hepática
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Hepatomegalia
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Humans
Idioma:
Ko
Revista:
Clinical Pediatric Hematology-Oncology
Ano de publicação:
2016
Tipo de documento:
Article