Case Series on Drug Reaction with Eosinophilia and Systemic Syndrome (DRESS) with Different Ocular Manifestation

ABSTRACT

@#“Drug reaction with eosinophilia and systemic syndrome” (DRESS) is a rare type of “severe cutaneous adverse reaction” (SCAR). We report 3 patients with DRESS who had different presentations. The first case developed DRESS following initiation of Allopurinol a month earlier. He presented with bilateral pseudomembranous conjunctivitis which resolved after 2 weeks. Two months later he presented with bilateral severe meibomian gland dysfunction (MGD), ocular surface disease (OSD) with severe dry eyes and left eye corneal perforation. The second case developed DRESS following initiation of allopurinol and had bilateral conjunctivitis. As for the third case, DRESS happened after taking Roxithromycin. She was diagnosed to have bilateral MGD, blepharitis and dry eyes. Case 2 and 3 did not develop ocular long-term complications. DRESS can cause acute and long-term ocular complications and therefore, following up patients with DRESS is essential to treat any complications with the aim to prevent corneal perforation.