Advance of research on endoplasmic reticulum stress and genetic epilepsy / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 756-761, 2023.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-981821
Biblioteca responsável:
WPRO
ABSTRACT
Epilepsies are a group of chronic neurological disorders characterized by spontaneous recurrent seizures caused by abnormal synchronous firing of neurons and transient brain dysfunction. The underlying mechanisms are complex and not yet fully understood. Endoplasmic reticulum (ER) stress, as a condition of excessive accumulation of unfolded and/or misfolded proteins in the ER lumen, has been considered as a pathophysiological mechanism of epilepsy in recent years. ER stress can enhance the protein processing capacity of the ER to restore protein homeostasis through unfolded protein response, which may inhibit protein translation and promote misfolded protein degradation through the ubiquitin-proteasome system. However, persistent ER stress can also cause neuronal apoptosis and loss, which may aggravate the brain damage and epilepsy. This review has summarized the role of ER stress in the pathogenesis of genetic epilepsy.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apoptose
/
Retículo Endoplasmático
/
Epilepsia
/
Resposta a Proteínas não Dobradas
/
Estresse do Retículo Endoplasmático
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2023
Tipo de documento:
Artigo