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Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis / 亚洲男科学杂志(英文版)
Asian Journal of Andrology ; (6): 375-381, 2023.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-981946
Biblioteca responsável: WPRO
ABSTRACT
Bisphenol A is a common environmental factor and endocrine disruptor that exerts a negative impact on male reproductive ability. By exploring bisphenol A-induced testicular cell death using the Institute of Cancer Research (ICR) mouse model, we found that a ferroptosis phenomenon may exist. Mice were divided into six groups and administered different doses of bisphenol A via intragastric gavage once daily for 45 consecutive days. Serum was then collected to determine the levels of superoxide dismutase and malondialdehyde. Epididymal sperm was also collected for semen analysis, and testicular tissue was collected for ferritin content determination, electron microscope observation of mitochondrial morphology, immunohistochemistry, real-time quantitative polymerase chain reaction, and western blot analysis. Exposure to bisphenol A was found to decrease sperm quality and cause oxidative damage, iron accumulation, and mitochondrial damage in the testes of mice. In addition, bisphenol A was confirmed to affect the expression of the ferroptosis-related genes, glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1), cyclooxygenase 2 (COX2), and acyl-CoA synthetase 4 (ACSL4) in mouse testicular tissues. Accordingly, we speculate that bisphenol A induces oxidative stress, which leads to the ferroptosis of testicular cells. Overall, the inhibition of ferroptosis may be a potential strategy to reduce male reproductive toxicity caused by bisphenol A.
Assuntos

Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Neoplasia dos Testículos Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Sêmen / Testículo / Estresse Oxidativo / Ferroptose Limite: Animais Idioma: Inglês Revista: Asian Journal of Andrology Ano de publicação: 2023 Tipo de documento: Artigo
Texto completo: Disponível Contexto em Saúde: ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis Problema de saúde: Neoplasia dos Testículos Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Sêmen / Testículo / Estresse Oxidativo / Ferroptose Limite: Animais Idioma: Inglês Revista: Asian Journal of Andrology Ano de publicação: 2023 Tipo de documento: Artigo
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