Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media / 法医学杂志
Journal of Forensic Medicine
; (6): 188-190, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-983985
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.@*METHODS@#The CD63 expression of basophilic granulocyte in blood was detected by flow cytometry. The levels of MC-CPA3 in blood serum and SC5b-9 in blood plasma were detected by ELISA.@*RESULTS@#The CD63 expression of basophilic granulocyte in blood, the levels of MC-CPA3 and SC5b-9 of anaphylaxis to non-ionic contrast media and β-lactam drugs were significantly higher than that in normal immune group (P < 0.05).@*CONCLUSION@#There is activation of basophilic granulocytes, mast cells and complement system in anaphylaxis to non-ionic contrast media. BAT can be used to diagnose the anaphylaxis to non-ionic contrast media.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Basófilos
/
Complexo de Ataque à Membrana do Sistema Complemento
/
Meios de Contraste
/
Carboxipeptidases A
/
Tetraspanina 30
/
Citometria de Fluxo
/
Granulócitos
/
Anafilaxia
/
Mastócitos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Forensic Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo