Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure
Yonsei Medical Journal
; : 63-70, 2008.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-98880
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The objective of this study was to determine whether the progressive increase of metabolic syndrome (MetS) score, the number of components of MetS, is correlated significantly with increasing pulse pressure (PP). MATERIALS ANDMETHODS:
4,034 subjects were enrolled from the Cardiovascular Genome Center of Yonsei University (MF=23441690, 55.2 +/- 10.5). Most of the study population were recruited from hypertension clinics, controlled with medications according to JNC7 guidelines. The Asian modified criteria of MetS were applied and MetS score was estimated. The HOMA index for insulin resistance, cholesterol profiles, and anthropometric measurements were assessed.RESULTS:
Among 4034 participants, 1690 (41.9%) were classified as MetS. Progressive increase in PP was demonstrated for increasing components of the MetS score. Multiple linear regression analysis with PP as the dependent variable showed that age (beta=0.311, p < 0.001), MetS score (beta=0.226, p < 0.001), male gender (beta=-0.093, p < 0.001) and HOMA index IR (beta=0.033, p=0.03) are significantly associated with PP (R(2)=0.207, p < 0.001).CONCLUSION:
The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pressão Sanguínea
/
Distribuição por Idade
/
Síndrome Metabólica
Tipo de estudo:
Guia de prática clínica
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2008
Tipo de documento:
Artigo