Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice / 한국실험동물학회지
Laboratory Animal Research
; : 123-129, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-98978
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glycine max
/
Bacillus
/
Bacillus subtilis
/
Peso Corporal
/
Colesterol
/
1-Desoxinojirimicina
/
LDL-Colesterol
/
Fígado
/
Camundongos Obesos
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Laboratory Animal Research
Ano de publicação:
2012
Tipo de documento:
Artigo