Targeted therapy for biliary tract carcinomas / 中华肝胆外科杂志

ABSTRACT

Biliary tract carcinomas (BTC) is characterized by high hetergenity. Despite being classified as rare cancers worldwide, the incidence of biliary tract carcinomas is increasing in China due to significant geographic variation. The current global needs for the treatment of BTC are far from being met, with advanced chemotherapy providing only limited survival benefits. Molecular targeted therapy, immunotherapy, and drug combination therapy have begun to flourish in recent years as its genetic characteristics are gradually revealed. This review summarized the therapeutically important targets of BTC, such as fibroblast growth factor receptor, isocitrate dehydrogenase and neurotrophic tyrosine receptor kinase as well as the advances in the research and development of their inhibitors, and prospects for precision targeted therapy for BTC.