Effects of Ondansetron on the Neuromuscular Block of Vecuronium, Rocuronium or Atracurium in a Rat Phrenic Nerve-Hemidiaphragm Preparation / 대한마취과학회지
Korean Journal of Anesthesiology
; : 650-655, 2003.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-9992
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Ondansetron, a 5-HT3 receptor antagonist, is widely used for the prevention of postoperative nausea and vomiting. However, the interaction of ondansetron with non-depolarizing muscle relaxants have not been reported until now. Therefore we studied the effects of ondansetron on the neuromuscular block of vecuronium, rocuronium or atracurium in vitro.METHODS:
A square wave 0.1 Hz supramaximal stimuli was applied to the phrenic nerve-hemidiaphragm preparation of a rat, and the twitch height response was recorded mechanomyographically. We measured cumulative concentration response curves of vecuronium, rocuronium or atracurium alone and after pretreating with ondansetron (1microgram/ml). We also measured the effects of ondansetron. The EC50's and EC90's of these muscle relaxants alone and after pretreatment with ondansetron were calculated using an inhibitory sigmoid Emax model.RESULTS:
Ondansetron depressed the twitch height in a dose-dependent manner, and its potency was lower than the muscle relaxants. The EC50 and EC90 of ondansetron were 14.7microgram/ml and 33.4microgram/ml, respectively. Pretreated ondansetron (1microgram/ml) significantly reduced the EC50's and EC90's of vecuronium, rocuronium and atracurium (P<0.05).CONCLUSIONS:
Ondansetron itself may have neuromuscular blocking properties, and it significantly enhances the neuromuscular blocks induced by vecuronium, rocuronium or atracurium.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Colo Sigmoide
/
Atracúrio
/
Brometo de Vecurônio
/
Ondansetron
/
Fármacos Neuromusculares não Despolarizantes
/
Bloqueio Neuromuscular
/
Náusea e Vômito Pós-Operatórios
/
Receptores 5-HT3 de Serotonina
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2003
Tipo de documento:
Artigo