ABSTRACT
This paper reviews the susceptibility profiles of Neisseria gonorrhoeae over a 20-year period in the Pretoria region. Endourethral specimens were collected from adult men with symptoms of urethritis attending primary health care clinics and private medical practitioners. These swabs were plated on enriched media for isolation of N. gonorrhoeae. Antimicrobial susceptibility of the organisms was performed using the disc diffusion and agar dilution methods. Plasmid analyses were performed on beta-lactamase-producing isolates. Penicillase-producing N. gonorrhoeae strains increased from 4to 16; whilst chromosomally mediated penicillin-resistant strains increased dramatically from 0to 16from 1984 to 2004. There was an equal distribution of the 3.2 MDa African and 4.4 MDa Asian plasmids. High-level tetracycline-resistant strains (36) were detected for the first time in 2004. Ciprofloxacin resistance emerged at 7in the same year. Gonococcal isolates remained susceptible to cefoxitin; ceftriaxone; cefpodoxime; and spectinomycin. However; the minimum inhibitory concentration values for spectinomycin were very close to the breakpoint. We have shown a continuing increase in resistance to penicillin (plasmid and chromosomal); the emergence of high-level tetracycline resistance and an emergence of resistance to ciprofloxacin. Susceptibility testing is essential for successful therapeutic outcomes and needs to be performed in an ongoing basis
Subject(s)
Anti-Bacterial Agents , Drug Resistance , Neisseria gonorrhoeae , Parasitic Sensitivity TestsABSTRACT
Abstract:This paper reviews the susceptibility profiles of Neisseria gonorrhoeae over a 20-year period in the Pretoria region. Endourethral specimens were collected from adult men with symptoms of urethritis attending primary health care clinics and private medical practitioners. These swabs were plated on enriched media for isolation of N. gonorrhoeae. Antimicrobial susceptibility of the organisms was performed using the disc diffusion and agar dilution methods. Plasmid analyses were performed on beta-lactamase-producing isolates. Penicillase-producing N. gonorrhoeae strains increased from 4 to 16; whilst chromosomally mediated penicillin-resistant strains increased dramatically from 0 to 16 from 1984 to 2004. There was an equal distribution of the 3.2 MDa African and 4.4 MDa Asian plasmids. High-level tetracycline-resistant strains (36) were detected for the first time in 2004. Ciprofloxacin resistance emerged at 7 in the same year. Gonococcal isolates remained susceptible to cefoxitin; ceftriaxone; cefpodoxime; and spectinomycin. However; the minimum inhibitory concentration values for spectinomycin were very close to the breakpoint. We have shown a continuing increase in resistance to penicillin (plasmid and chromosomal); the emergence of high-level tetracycline resistance and an emergence of resistance to ciprofloxacin. Susceptibility testing is essential for successful therapeutic outcomes and needs to be performed in an ongoing basis
Subject(s)
Adult , Anti-Infective Agents , Delivery of Health Care , Gonorrhea , Men , Neisseria gonorrhoeaeABSTRACT
Moins frequent que chez la femme; le cancer du sein existe aussi chez l'homme. A partir d'une serie hospitaliere a Niamey au Niger; nous avons entrepris une etude retrospective afin d'en analyser les particularites epidemiologiques cliniques et therapeutiques. Durant la periode d'etudes (1992-2006); nous avons collige 18 cas microscopiquement confirmes. La majorite des malades etaient d'origine rurale. Ils se sont presentes a des stades avances : T3 et T4. Toutes les malades ont ete operees; seules 4 parmi elles ont eu un traitement complementaire adjuvant. Le carcinome canalaire infiltrant a ete le type histologique le plus frequent (55;5). L'evolution n'a pu etre evaluer car tous les malades etaient perdues de vue 6 mois apres l'acte operatoire