ABSTRACT
Background: Type 1 diabetes mellitus is an autoimmune disease caused by destruction of pancreatic islet beta cells and characterized by defect in insulin secretion. Objectives: The present study was carried out to investigate the hypoglycemic effects of Allium cepa in patients with type 1 diabetic patients. Results: In the assessment of the hypoglycaemic activity of Allium cepa in type 1 diabetic patients (n=21); crude Allium cepa (100g) caused a considerably lowered value in the fasting blood glucose levels by about 89 mg/dl in relation to insulin (145 mg/dl) after 4 hours. Also the ingestion of crude Allium cepa by type 1 diabetic patients produced a significant reduction in the induced hyperglycemia (GTT) by about 120 mg/dl in relation to water (77 mg/dl) and the standard drug insulin (153 mg/dl). Conclusion: Crude Allium cepa produced hypoglycemic effects; thus it could be used as a dietary supplement in management of diabetes