Acute and Subacute Toxicity of Aspilia Africana Leaves

This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity; 5 doses of 2; 4; 8; 12 and 16g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver; kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD50) was found to be greater in females than males with an average of 6.6g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT; AST; ALP; Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand; most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity

Acute and subacute toxicity of aspilia africana leaves

This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity; 5 doses of 2; 4; 8; 12 and 16g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver; kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD50) was found to be greater in females than males with an average of 6.6g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT; AST; ALP; Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand; most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity

Evaluation of Antimicrobial Activity of the Stem Bark of Cylicodiscus Gabunensis (Mimosaceae)

Ethyl acetate (EA) extract of the stem bark of Cylicodiscus gabunensis (CG) was analysed phytochemically and evaluated for its antimicrobial activity against 17 pathogenic species isolated from patient: Escherichia coli; Klebsiella pneumoniae; Shigella dysenteriae; Shigella flexneri; Morganella morganii; Proteus vulgaris; Proteus mirabilis ; Salmonella typhi; Citrobacter freundii; Enterobacter cloacae; Enterobacter agglomerans; Staphylococcus aureus; Streptococcus feacalis; Pseudomonas aeruginosa; Bacillus cereus T; Candida albicans and Candida glabrata. Flavonoids; saponins; tannins; polyphenols; coumarins; triterpenes and/or sterols and reducing sugars were detected in the (EA) extract of CG. The best MIC and MBC values for the microorganisms sensitive to the extract were 0.00078 and 0.00315 mg/ml respectively. The greater and remarkable antimicrobial activity of the (EA) extract of CG was recorded with Staphylococcus aureus; Proteus vulgaris and Bacillus cereus T. These results provide a rationalization for the traditional use of this plant for the treatment of infections diseases