Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi

Protection afforded BCG vaccines against tuberculosis and leprosy varies widely between different populations. In the only controlled trial which assessed protective efficacy of BCG (Danish and Pasteur strains) against both diseases; there was slightly more protection against leprosy than against tuberculosis. Protection was estimated at 50 percent or greater against leprosy; and there was no evidence for lower protection against multibacillary than against paucibacillary disease. There was no statistically significant protection by BCG against tuberculosis in this population

The anatomical distribution of single leprosy lesions in an African population; and its implications for the pathogenesis of leprosy

Data on the anatomical sites of single leprosy lesions found in 635 newly diagnosed and biopsy-confirmed leprosy patients are presented. These patients were found during total population surveys carried out by the Lepra Evaluation Project; a prospective longitudinal study of the epidemiology of leprosy in Karonga District; Northern Malawi. There was a striking excess of single lesions on the face and the back of the arms; compared to the distribution of skin surface area; and a deficit on the legs; regardless of age. There is some evidence for a sex difference in lesion distribution among adults; with facial and arm lesions being relatively more common in females and back lesions being more common in males. The excess of lesions on the face compared to the lower limbs is similar to data from Uganda; but very unlike data from Burma and elsewhere in Asia. Overall; the distribution of lesions does not suggest a pattern reflecting entry of Mycobacterium leprae; nor does it suggest an association with anatomical distribution of the nervous or vascular system. It is argued that the distribution reflects the influence of some 'local' environmental or behavioural factors. Author.90.Z1-542-363-300901121