Clinical Abdominal Palpation for Predicting Oligohydramnios in Suspected Prolonged Pregnancy

Objective. In view of the scarcity of ultrasound in low-resource settings; to evaluate abdominal palpation for prediction of oligohydramnios in suspected prolonged pregnancy; using the ultrasound-obtained amniotic fluid index (AFI) as a gold standard; taking into account maternal and fetal factors that may affect amniotic fluid volume. Methods. A cross-sectional analytical study at Chris Hani Baragwanath Academic Hospital; Johannesburg; South Africa; on women referred from midwife-run clinics with suspected gestational age ?41 weeks. Eligible women had their AFI measured; then had abdominal palpation by the researcher; who was blinded to exact gestational age and AFI findings. Palpation focused on ballottability of fetal parts; ease of feeling fetal parts; and impression of fetal compaction. Gestational age was then recalculated using information from earlier ultrasound scans and menstrual dates. Univariable and multivariable logistic regression was performed with oligohydramnios (AFI 5 cm) as the dependent variable.Results. Of 100 women; 45 had a recalculated gestational age ?41 weeks. Twenty-three had oligohydramnios. Gestational age was a significant independent predictor for oligohydramnios (odds ratio (OR) 1.78; 95 confidence interval (CI) 1.08 - 2.94). The only component of palpation significantly associated with oligohydramnios; after adjustment for gestational age; was non-ballottability of the presenting part (adjusted OR 4.02; 95 CI 1.05 - 15.4). Non-ballottability had a sensitivity and specificity for oligohydramnios of 87 and 40; respectively; with a negative predictive value of 91.Conclusion. When ultrasound is not available; ballottability of the presenting part may have value for excluding oligohydramnios and assisting clinical decisions in suspected prolonged pregnancy

Nuchal Translucency as a Method of First-Trimester Screening for Aneuploidy

Objective. To determine the effectiveness of nuchal translucency (NT) screening in predicting aneuploidy and structural abnormalities in a South African population. Study design. Descriptive study. Setting. Chris Hani Baragwanath Hospital fetal medicine unit. Outcome measures. An adjusted risk was derived from the combination of maternal age-related risk and the risk derived from NT screening. A positive screen was denoted by an adjusted risk of more than 1/300 and a negative screen by an adjusted risk of less than 1/300. In order to determine the number of undiagnosed abnormalities in the group; all babies were examined by a paediatrician at birth to detect and describe dysmorphic features. Results. A total of 428 patients underwent first-trimester screening between July 2003 and July 2005. Three per cent were lost to follow-up. Of the 415 patients analysed; 59 screened positive and 356 screened negative. The mean age for both groups of patients was 30.1 years. Of the 57 patients who screened positive; 24 elected to have chorionic villus sampling (CVS). This resulted in the detection of 6 chromosomal abnormalities and 2 structural abnormalities. Among the remaining 356 patients; who had screened negative; 2 had an increase in the adjusted risk when the risk was compared with the background risk; and 1 chromosomal abnormality was detected in this group; 8 elected to have CVS because of a previous history of a chromosomal abnormality; and there were no abnormalities among them. Conclusions. The use of these screening methods has enabled prenatal karyotyping to become cost effective; and allows concentration on pregnancies at highest risk for chromosomal abnormalities; regardless of age