ABSTRACT
In this study a crude aqueous extract from fresh leaves and twigs of khat (Miraa) was investigated for its effects in vitro on rabbit's doudenum and perfused heart preparation. There was a significant reduction in spontaneous contraction of the duodenum in the presence of increasing doses of khat extracts. On the rabbit's heart; khat caused an inhibition of spontaneous contractions. It is therefore suggested that chronic habitual abuse of khat may predispose to gastrointestinal and cardiovascular problems in human subjects
Subject(s)
Cardiovascular System , Digestive System , NarcoticsABSTRACT
It is recommended that for individuals weighting 45 to 55kg a dose of chloroquine of 600mg on first day 300mg on second day and 150mg on third day would give desired therapeutic non-toxic levels whereas for heavier individuals (80-90kg) the appropriate dosage would be 5 tablets (750mg) first day; 4 tablets (600mg) second day and 3 tablets (450mg) on third day