Communication: Matrix type transdermal drug delivery systems of metoprolol tartrate: skin toxicity and in vivo characterization

Transdermal drug delivery systems (TDDS) of metoprolol were previously fabricated and evaluated in vitro. The TDDS was composed of polymers Eudragit RL 100 and polyvinyl pyrrolidone K-30 in 8:2; 4:6; 6:4 and 2:8 fractions in formulations MT-1; MT-2 MT-3 and MT-4; respectively. All formulations carried 10