ABSTRACT
Background: Induction of labor for postdate pregnancy using misoprostol is one of the most common interventions in pregnancy. However; the optimal dose of misoprostol is yet to be determined with previous reports utilizing different dosages. Objective: The main objective of this study was to compare the effectiveness and safety of 25 ?g versus 50 ?g of intravaginal misoprostol for induction of labor in nulliparous women with postdate pregnancy. Methodology: This was a prospective study in which 88 nulliparous women with postdate pregnancy were randomly selected to receive either 25 ?g or 50 ?g of misoprostol for induction of labor. Student's t-test and Chi-square test were used to compare proportions. Results: There was no significant difference between the two groups with regard to the induction-vaginal delivery interval between the two doses. The proportion of women delivering vaginally with a single dose of misoprostol (11/40 vs. 23/43; P = 0.01) and vomiting were significantly greater in the 50 ?g group. However; there was no significant difference between both groups in terms of the need for augmentation of labor; caesarean section; tachysystole and hyperstimulation syndrome. Conclusion: Intravaginal administration of 25 ?g of misoprostol appears to be as effective; but safer than 50 ?g for induction of labor in nulliparous women with postdate pregnancy