Cotrimoxazole for childhood febrile illness in malaria-endemic regions

The efficacy of co-trimaxozole for the treatment of Plasmodium falciparum parasitaemia in children younger than 5 years of age was evaluated in Malawi. 46 children with P falciparum parasitaemia; 37 percent of whom also met clinical criteria for acute respiratory tract infection; were treated with 20 mg/kg co-trimaxozole twice daily for five days. Parasitaemia (mean clearance time 2.7 days) and syptoms were rapidly abolished and improvement was maintained during the follow-up 14 days. Co-trimaxozole may be an effecitve single treatment for febrile illness in young children in areas where malaria is endemic; resources are few; and diagnosis must rely on clinical findings alone

An evaluation of clinical indicators for severe paediatric illness

To help reduce paediatric morbidity and mortality in the developing world; WHO has developed a diagnostic and treatment algorithm that targets the principal causes of death in children; which include acute respiratory infection; malaria; measles; diarrhoeal disease; and malnutrition. With this algorithm; known as the Sick Child Charts; severely ill children are rapidly identified; through the presence of any one of 13 signs indicative of severe illness; and referred for more intensive health care. These signs are the inability to drink; abnormal mental status (abnormally spleepy); convulsions; wasting; oedema; chest wall retraction; stridor; abnormal skin turgor; repeated vomiting; stiff neck; tender swelling behind the ear; pallor of the conjunctiva; and corneal ulceration. The usefulness of these signs; both in current clinical practice and within the optimized context of the Sick Child Chart algorithm in a rural district of Western Kenya; was evaluated. We found that 27of children seen in outpatient clinics had one or more of these signs and that pallor and chest wall retraction were the signs most likely to be associated with hospital admission (odds ratio (OR) = 8.6 and 5.3; respectively). Presentation with any of these signs led to a 3.2 times increased likelihood of admission; although 54of hospitalized children had no such signs and 21of children sent home from the outpatient clinic had at least one sign. Among inpatients; 58of all children and 89of children who died had been admitted with a sign. Abnormal mental status was the sign most highly associated with death (OR = 59.6); followed by poor skin turgor (OR=5.6); pallor (OR=4.3); repeated vomiting (OR=3.6); chest wall retraction (OR=2.7); and oedema (OR=2.4). Overall; the mortality risk associated with having at least one sign was 6.5 times higher than that for children without any sign. While these signs are useful in idnetifying a subset of children at high risk of death; their validation in other settings is needed. The training and supervision of health workers to identify severely ill children should continue to be given high priority because of the benefits; such as reduction of childhood mortality