ABSTRACT
Trichomonas vaginalis is an important and common cause of urogenital infections in both developed and in developing countries. In view of the high prevalence; increase in resistance to drug therapy and associated risk of acquisition and transmission of HIV; we screened the aqueous extracts of 29 plants. These plants are used to treat venereal diseases and infections in the Venda region. Extracts of four plants showed trichomonicidal activity: Securidaca longepedunculata Fresen. (Polygalaceae; 0.10 mg/ml); Solanum aculeastrum Dun. (Solanaceae; 1.06 mg/ml); Piper capense L.f. (Piperaceae; 11.19 mg/ml) and Cassine transvaalensis (Burtt. Davy) Codd (Celastraceae; 9.69 mg/ml). Further investigations are required to determine whether these plants possess the potential to be developed as new drugs for the treatment of trichomoniasis