ABSTRACT
Tuberculosis is again becoming a major public health problem. In order to control this complex disease; case-management; chemoprophylaxis and vaccination are used. The aim of case-management is to virtually stop transmission of tuberculosis infection by multidrug chemotherapy. This is; however; hampered by poor drug compliance and the high cost of the most effective drugs. Bacilli-Calmette-Guerin (BCG) vaccination has been used for a long time but with contentious efficacy. Though recent studies put the efficacy at 50; its cost-effectiveness has yet to be established. Isoniazid preventive therapy (1PT) for control of tuberculosis is also rapidly gaining acceptance. In patients who adhere to 80of medication taken; the efficacy is usually high. As for the control of tuberculosis among health care workers; engineering; administrative and personal respiratory measures have been introduced. Following the introduction of these measures in USA; dramatic decline in the risk of tuberculosis among these workers has occurred